Objective: To compare characteristics and outcomes in patients who had radiotherapy (RT) for prostate cancer (PCa) and underwent urinary diversion (UD) due to prostatic fistula (Fistula) vs localized radiation injury (Localized).
Methods: This study was a retrospective single-institution study. Exclusion criteria included follow-up <3 months, large pelvic tumor, and surgery for cancer control.
The data presented here consists of library spectra obtained for use with a laser absorption spectroscopy gas sensor. The spectra include absorbance data for SO, SO, HO and HSO at 300° C and 350° C temperatures in two wavelength bands, 7-8 µm and 8-9 µm. Datasets were collected in a heated multi-pass absorption Herriott cell using two tunable external cavity quantum cascade laser sources, with the resulting transmission signal measured using a thermoelectrically cooled MCT detector.
View Article and Find Full Text PDFCapillary Absorption Spectroscopy (CAS) is a relatively new analytical technique for performing stable isotope analysis. Here, we demonstrate the utility of CAS by recording and quantifying variation in C in controlled and biologically relevant applications. We calibrated CAS system response to increased CO, with an observed ∼4‰ increase in measured ΔC for each 0.
View Article and Find Full Text PDFA panel of 10 IgG enzyme-linked immunosorbent assays (ELISAs) were developed for the detection of anti-microbial immune responses in the cerebrospinal fluid (CSF) of patients with demyelinating diseases (DD). The anti-microbial ELISA assays follow on prior human brain tissue RNA sequencing studies that established multiple sclerosis (MS) microbial candidates. Lysates included in the ELISA panel were derived from Akkermansia muciniphila, Atopobium vaginae, Bacteroides fragilis, Lactobacillus paracasei, Odoribacter splanchnicus, Pseudomonas aeruginosa, Cutibacterium (Propionibacterium) acnes, Fusobacterium necrophorum, Porphyromonas gingivalis, and Streptococcus mutans.
View Article and Find Full Text PDFMultiple sclerosis (MS) is an autoimmune disease characterized by multiple lesions in the brain and spinal cord. We used RNA sequencing to identify microbial sequences and characterize human gene expression patterns in 30 human brain biopsy specimens. RNAs which aligned to known microbial taxa, were significantly enriched in 10 of 12 primary demyelination (MS) brain specimens compared to a group of 15 epilepsy controls, leading to a list of 29 MS microbial candidate genera from 11 different phyla.
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