Critical Regions and Connections Form Pathways and Clusters in the Mouse Brain.

Connectome network analysis across multiple species should help identify principles of brain function. Here, we examined three fundamental properties-global efficiency, global betweenness centrality, and global clustering-in the mesoscale tract-tracing data of the mouse connectome; and conducted vulnerability analysis to identify the critical regions and connections based on the loss in network function when each brain region (213) and connection (16,594) was removed. Robustness tests examining noise effects were also conducted.

Selective Block of Upregulated Kv1.3 Potassium Channels in ON-Bipolar Cells of the Blind Retina Enhances Optogenetically Restored Signaling.

Loss of photoreceptors in retinal degenerative diseases also impacts the inner retina: bipolar cell dendrites retract, neurons rewire, and protein expression changes. ON-bipolar cells (OBCs) represent an attractive target for optogenetic vision restoration. However, the above-described maladaptations may negatively impact the quality of restored vision.

The Bovine Ex Vivo Retina: A Versatile Model for Retinal Neuroscience.

Purpose: The isolated ex vivo retina is the standard model in retinal physiology and neuroscience. During isolation, the retina is peeled from the retinal pigment epithelium (RPE), which plays a key role in the visual cycle. Here we introduce the choroid-attached bovine retina as an in vivo-like model for retinal physiology.

Bipolar cell targeted optogenetic gene therapy restores parallel retinal signaling and high-level vision in the degenerated retina.

Optogenetic gene therapies to restore vision are in clinical trials. Whilst current clinical approaches target the ganglion cells, the output neurons of the retina, new molecular tools enable efficient targeting of the first order retinal interneurons, the bipolar cells, with the potential to restore a higher quality of vision. Here we investigate retinal signaling and behavioral vision in blind mice treated with bipolar cell targeted optogenetic gene therapies.

How 'who someone is' and 'what they did' influences gossiping about them.

To understand, predict, and help correct each other's actions we need to maintain accurate, up-to-date knowledge of people, and communication is a critical means by which we gather and disseminate this information. Yet the conditions under which we communication social information remain unclear. Testing hypotheses generated from our theoretical framework, we examined when and why social information is disseminated about an absent third party: i.