This descriptive, cross-sectional study aimed to identify whether having a chronic leg ulcer (CLU), in addition to diabetes, contributed to frailty in individuals ≥65 years old. It also explored the associations between frailty, pre-frailty and other factors. 125 participants aged ≥65 attending outpatient clinics in Ireland were categorised into three groups: (1) diabetes-only and no CLU, (2) CLU-only and no diabetes, and (3) diabetes and CLU.
View Article and Find Full Text PDFDiabetic foot ulcers (DFUs) are a major complication of diabetes mellitus, defined as infection, ulceration and/or destruction of deep tissues and/or peripheral artery disease in the lower extremities. Efficient cleansing is essential for the treatment of wounds, as it removes debris and necrotic tissue and decreases the burden of wound-colonizing microorganisms. The objective was to conduct a systematic review of the literature to investigate the effects of wound cleansing agents commonly used in DFU care, compared to the use of normal saline for DFU management.
View Article and Find Full Text PDFPurpose: Genomic tests, such as the Oncotype Dx 21-gene and Prosigna risk of recurrence (ROR-P) assay, are commonly used for breast cancer prognostication. Emerging data suggest variability between assays, but this has not been compared in diverse populations.
Materials And Methods: RNA sequencing was performed on 647 previously untreated stage I-III estrogen receptor-positive/human epidermal growth factor receptor 2-negative tumors in the Carolina Breast Cancer Study, which oversampled Black and younger women (age <50 years at diagnosis), using research versions of two common RNA-based prognostic assays: ROR-P and the 21-gene recurrence score (RS).