Publications by authors named "J D Greil"
We investigate the effect of focused-ion-beam (FIB) irradiation on spin waves with sub-micron wavelengths in yttrium-iron-garnet films. Time-resolved scanning transmission x-ray microscopy was used to image the spin waves in irradiated regions and deduce corresponding changes in the magnetic parameters of the film. We find that the changes of Gairradiation can be understood by assuming a few percent change in the effective magnetizationMeffof the film due to a trade-off between changes in anisotropy and effective film thickness.
View Article and Find Full Text PDFBackground: The incorporation of anti-GD2 antibodies such as ch14.18/SP2/0 into the multimodal treatment of high-risk neuroblastoma (HR-NB) patients has improved their outcomes. As studies assessing the long-term outcomes, long-term sequelae, and health-related quality of life (HRQoL) of this treatment are limited, this retrospective analysis aimed to explore these.
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- Treosulfan is an important treatment in allogeneic haematopoietic stem cell transplantation (allo-HSCT) for children, offering lower toxicity than traditional drugs.
- Researchers studied the effects of treosulfan on 83 pediatric patients to see how it impacts survival, graft failure, and graft-versus-host disease.
- The results showed no significant correlation between treosulfan exposure and clinical outcomes or toxicity, indicating that standardized dosing is effective for pediatric allo-HSCT.
Article Synopsis
- Gene addition and editing therapies for β-thalassemia, particularly betibeglogene autotemcel (beti-cel), show promise as potentially curative options, with real-world studies demonstrating their effectiveness and safety.* -
- Out of 15 patients evaluated for treatment with beti-cel, 8 were treated post-busulfan conditioning, achieving transfusion independence within 8 to 59 days, while experiencing some acute toxicity typical of the conditioning regimen.* -
- Monitoring of patients revealed several unexpected side effects, including endocrine dysfunction, posttreatment depression and anxiety in one patient, and fatigue impacting quality of life in another, underscoring the need for careful management of these complications.*
Background: Neuroblastoma is the most common extracranial solid tumour in children. Relapsed or refractory neuroblastoma is associated with a poor outcome. We assessed the combination of irinotecan-temozolomide and dasatinib-rapamycin (RIST) in patients with relapsed or refractory neuroblastoma.
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