Toward Origami-Inspired In Vitro Cardiac Tissue Models.

The advancement of engineered cardiac tissue-based patches is paramount for providing viable solutions for restoring cardiac function through implantation. Numerous techniques described in the literature aim to provide diverse mechanical and topographical cues simultaneously, fostering enhanced cardiac maturation and functionality. Among these, cellulose paper-based scaffolds have gained attention owing to their inherent benefits, such as biocompatibility and ease of chemical and physical modification.

Training on a 3D-Printed Simulation Model Improves Accuracy in External Ventricular Drain Placement.

Background And Objectives: External ventricular drain (EVD) placement is a critical, lifesaving procedure in cranial neurosurgery, often performed manually using anatomical landmarks that vary between individuals. This study evaluates the efficacy of a 3-dimensional (3D)-printed EVD training model designed to improve the accuracy of this procedure.

Methods: Computed tomography scans from 3 patients were used to create 3D-printed head models with narrow, wide, and normal ventricles.

User-centric design of a 3D search interface for protein-ligand complexes.

In this work, we present the frontend of GeoMine and showcase its application, focusing on the new features of its latest version. GeoMine is a search engine for ligand-bound and predicted empty binding sites in the Protein Data Bank. In addition to its basic text-based search functionalities, GeoMine offers a geometric query type for searching binding sites with a specific relative spatial arrangement of chemical features such as heavy atoms and intermolecular interactions.

Biomechanical analysis of the human derived soft tissue graft Epiflex for use in oral soft tissue augmentation.

Purpose: This study aimed to investigate the biomechanical properties, cell migration, and revascularization of the acellular dermal matrix Epiflex. As a decellularized, freeze-dried human skin graft, Epiflex has broad applications in medical fields, particularly in implantology and dentistry. Understanding its biomechanical characteristics is crucial for its clinical adoption as a novel soft tissue graft option.

Database-Driven Identification of Structurally Similar Protein-Protein Interfaces.

Analyzing the similarity of protein interfaces in protein-protein interactions gives new insights into protein function and assists in discovering new drugs. Usually, tools that assess the similarity focus on the interactions between two protein interfaces, while sometimes we only have one predicted interface. Herein, we present PiMine, a database-driven protein interface similarity search.