Publications by authors named "J D Fontes"
Introduction: The profile of genetic and nongenetic factors associated with progression to kidney failure (KF) in steroid-resistant nephrotic syndrome (SRNS) is largely unknown in admixed populations.
Methods: A total of 101 pediatric patients with primary SRNS were genetically assessed targeting Mendelian causes and status with a 62-NS-gene panel or whole exome sequencing, as well as genetic ancestry. Variant pathogenicity was evaluated using the American College Medical of Genetics and Genomics (ACMG) criteria.
Leishmaniasis is one of the most important neglected diseases, classically characterized by three clinical forms that if left untreated can lead to skin lesions, lifelong scarring, or death depending on the parasite species. Unfortunately, treatment is unsatisfactory and the search for an improved therapy has been a priority. Gold compounds have emerged as promising candidates and among them, Au(I)bis-N-heterocyclic carbene (Au(BzTMX)) has stood out.
View Article and Find Full Text PDFIntroduction: Intracranial lesions often require tissue diagnosis through stereotactic biopsies. Originating in the 1970s, this technique has progressed, but limitations and risks persist. Recently, robot-assisted techniques have made strides, providing the potential for safer and more precise procedures.
View Article and Find Full Text PDFBackground: Barbed sutures eliminate knots and may offer some advantages over conventional sutures. This meta-analysis compares clinical, surgical, and economic outcomes of barbed sutures with standard closure techniques in spinal surgery.
Methods: We systematically searched PubMed, Embase, and Web of Science for studies comparing barbed and conventional suture for patients undergoing spinal surgery.
Article Synopsis
- Research into the antitumor effects of gold compounds is gaining traction, with a focus on their complex action mechanisms.
- The primary mechanism studied is the inhibition of thioredoxin reductase by auranofin, which disrupts the redox balance in cells and induces oxidative stress leading to cell death.
- The review compiles data from the last ten years on how different gold compound structures affect reactive oxygen species (ROS) production and enzyme activity, revealing varied efficacy and potential alternative mechanisms beyond thioredoxin reductase inhibition.