Sex and Body Mass Index Differences in Changes in Skin Temperature After Repeated Sessions of Whole-Body Cryostimulation.

: Whole-body cryostimulation (WBC) involves exposure to extremely low temperatures to reduce inflammation and pain and to enhance recovery. Despite its growing popularity and the importance of the magnitude of WBC-induced skin cooling in triggering the cascade of effects, limited research has focused on skin temperature changes in individuals with severe obesity, where body composition and sex may influence outcomes. : To examine differences in the cooling response based on sex and BMI, we conducted an observational study comparing patients with obesity to normal-weight individuals after repeated WBC sessions.

Autonomic Modulation in Parkinson's Disease Using Whole-Body Cryostimulation: A Pilot Study.

Parkinson's disease (PD) is a multifaceted neurodegenerative disorder that progressively affects both the central and peripheral nervous systems. This pilot study aimed to examine the effects of repeated whole-body cryostimulation (WBC) sessions on the sympathovagal balance in PD patients and correlate heart rate variability (HRV) indexes with peripheral biomarkers of the autonomic nervous system (ANS). Seventeen PD patients with mild to moderate motor severity underwent a 10-session WBC cycle over 5 consecutive days.

Pilots, Astronauts, and the Aerospace Microbiota: A Narrative Review of Occupational Impact.

The human microbiota plays a crucial role in maintaining health and preventing disease; however, the effects of occupational exposure on the microbiota of aircrew and astronauts are not fully understood. This narrative review aims to synthesize the current knowledge on microbiota alterations in aerospace medicine, assess the potential of probiotics as a countermeasure, and identify key gaps that warrant further research. The references were identified through searching PubMed for English articles published between 2010 and 2024, using keywords related to microbiota, probiotics, aviation, spaceflight, pilots, and astronauts.

Lymphocytic choriomeningitis arenavirus utilises intercellular connections for cell to cell spread.

The Arenaviridae family of segmented RNA viruses contains nearly 70 species with several associated with fatal haemorrhagic fevers, including Lassa, Lujo and Junin viruses. Lymphocytic choriomeningitis arenavirus (LCMV) is associated with fatal neurologic disease in humans and additionally represents a tractable model for studying arenavirus biology. Within cultured cells, a high proportion of LCMV spread is between directly neighbouring cells, suggesting infectivity may pass through intercellular connections, bypassing the canonical extracellular route involving egress from the plasma membrane.