In emergency settings, does the use of testicular pulse oximetry aid diagnosis of testicular torsions?

Pulse oximetry is a non-invasive and inexpensive method of detecting oxygenation, which could help to reduce unnecessary scrotal exploration and expedite diagnosis if shown to be accurate in patients with suspected testicular torsion. A short systematic review was conducted to address the following three-part question: in emergency settings, can the use of testicular pulse oximetry aid the diagnosis of testicular torsion?The Medline, Embase and Cochrane databases were searched using the Ovid interface on 29 January 2025. The search included papers from 1946 on Medline, from 1974 on Embase and from 1998 on Cochrane.

Consistent Safety and Efficacy of Sotatercept for Pulmonary Arterial Hypertension in Mutation Carriers and Noncarriers: A Planned Analysis of Phase 2, Double-Blind, Placebo-controlled Clinical Trial (PULSAR).

Objectives: To evaluate the effect of genetic variant status on sotatercept efficacy and effect of sotatercept treatment on biomarkers in pulmonary arterial hypertension Methods: PULSAR (NCT03496207) was a phase 2, randomized, controlled study of sotatercept vs placebo added to background therapy for pulmonary arterial hypertension. Participants had DNA sequencing done at baseline to detect genetic variants in disease-associated genes (, and ). Safety (adverse events) and efficacy (pulmonary vascular resistance, 6-minute walk distance) were assessed by variant status and treatment at 24 weeks.

Therapy for Stage IV Non-Small Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2024.3.

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Access to Diagnostics and Treatment for People With Metastatic EGFR-Positive NSCLC: Lessons From Project PRIORITY.

Introduction: The treatment landscape for people diagnosed with EGFR-mutated (EGFR-m) NSCLC has rapidly evolved, yet there remains limited self-reported information about the lived experience. In this paper, we describe the clinical characteristics and treatment experiences of people living with EGFR-m lung cancer from Project PRIORITY, a patient-driven study.

Methods: An online survey was distributed among the EGFR Resisters community between April 2019 and January 2020.