Publications by authors named "J D Ehrhardt"

Introduction: Developmental disorders (DDs) affect approximately 1 in 6 children in the United States. Early identification and treatment improve developmental outcomes and child and family functioning. Disparities exist in the diagnosis of DD that leads to inequitable access to developmental services during important periods of neuroplasticity.

View Article and Find Full Text PDF

Renal cell carcinoma (RCC) is the most common form of kidney cancer, known for its immune evasion and resistance to chemotherapy. Evidence indicates that the SARS-CoV-2 virus may worsen outcomes for RCC patients, as well as patients with diminished renal function. Evidence suggests that the SARS-CoV-2 virus may exacerbate outcomes in RCC patients and those with impaired renal function.

View Article and Find Full Text PDF

, involved in carcinogenesis of colon carcinomas, has been described as part of the commensal flora of the female upper reproductive tract. Although its contribution to destructive inflammatory processes is well described, its role as commensal uterine bacteria has not been thoroughly investigated. Since carcinogenesis shares similar mechanisms with early pregnancy development (including proliferation, invasion, blood supply and the induction of tolerance), these mechanisms induced by could play a role in early pregnancy.

View Article and Find Full Text PDF
Article Synopsis
  • PAI-1 (Plasminogen activator inhibitor-1) traditionally functions as a secretory protease inhibitor, playing a role in preventing blood clot breakdown but reportedly has a complex relationship with tumor progression.
  • Recent research indicates that PAI-1 also localizes within the cytoplasm and nucleus, suggesting it may have additional unexplored intracellular functions.
  • The study reveals that PAI-1 has a nuclear export signal and is found in specific nuclear structures (PML bodies) linked to the growth of endothelial cells, implying its potential connection to aging and cancer development.
View Article and Find Full Text PDF