Publications by authors named "J D Earp"

The number of quantitative systems pharmacology (QSP) submissions to the U.S. Food and Drug Administration has continued to increase over the past decade.

View Article and Find Full Text PDF
Article Synopsis
  • - Inflammatory bowel disease (IBD) is a chronic condition with limited treatments that can have negative side effects; researchers developed a targeted probiotic system (EcN) to potentially treat it.
  • - This system uses a sensor to detect nitric oxide as a biomarker for inflammation and can secrete therapeutic nanobodies that work similarly to a common IBD drug, Adalimumab.
  • - The study also created a mathematical model to help understand and optimize how these probiotics interact and function, enhancing the possibilities for future IBD therapies through synthetic biology.
View Article and Find Full Text PDF
Article Synopsis
  • This study investigates how intramuscular stiffness in the hamstrings affects muscle strain during passive hip flexion, aiming to understand why strains occur.
  • Researchers measured the stiffness of three hamstring muscles in healthy participants and found that the proximal area (closer to the hip) was the least stiff and contributed the most to muscle strain.
  • The findings suggest that variations in stiffness within the hamstrings may increase the risk of strain injuries, especially in the proximal region during activities that involve hip flexion.
View Article and Find Full Text PDF
Article Synopsis
  • Passive hamstring stiffness changes along different parts of the muscle, which can lead to uneven strain during stretching and impact adaptations and injury risk.
  • A study with 30 active participants measured the effects of static stretching on the stiffness of three hamstring muscles: biceps femoris, semimembranosus, and semitendinosus, both immediately after stretching and after 4 weeks of stretching or no stretching.
  • Results showed that static stretching acutely decreased stiffness in the biceps femoris and semimembranosus but not in the semitendinosus, while chronic effects led to increased stiffness in the biceps femoris and semitendinosus but not in the semimembranosus, suggesting contrasting
View Article and Find Full Text PDF

Background: The activity profiles of football players during competition can be affected by the athletes' competitive level and sex. However, evidence of this in youth South American athletes is scarce as is the effects of body composition on match activity profiles. Therefore, the present study compared the activity profiles of Chilean under-20 (U20) and under-17 (U17) male and female teams during the World Cup qualification tournaments (WC) using a multicomponent athlete monitoring system and explored the relationships between these profiles and the players' body composition.

View Article and Find Full Text PDF