Discovery of Quinazolone Pyridiniums as Potential Broad-Spectrum Antibacterial Agents.

The overprescription of antibiotics in medicine and agriculture has accelerated the development and spread of antibiotic resistance in bacteria, which severely limits the arsenal available to clinicians for treating bacterial infections. This work discovered a new class of heteroarylcyanovinyl quinazolones and quinazolone pyridiniums to surmount the increasingly severe bacterial resistance. Bioactive assays manifested that the highly active compound exhibited strong inhibition against MRSA and with extremely low MICs of 0.

Comparative Transcriptomic Analysis Reveals New Insights into Spawn Aging in : Mitochondrial Dysfunction.

Spawn aging poses a substantial challenge to the industry. This study focuses on the role of mitochondrial dysfunction in the aging process of spawn. We conducted a comprehensive comparative transcriptome analysis to elucidate the molecular mechanisms underlying spawn aging.

Dietary Fiber-Rich Improves Intestinal Health and Antioxidant Capacity of Zhedong White Geese.

(SA), a plant rich in dietary fiber, has demonstrated considerable potential for enhancing gut health and antioxidant capacity in animals. This study investigates the integration of SA as a novel dietary ingredient for Zhedong white geese, with a specific focus on evaluating its effects on growth performance, nutrient digestibility, antioxidant capacity, intestinal health, and cecal microbiota composition. A total of 360 1-day-old Zhedong white geese with an average weight of 114.

All-in-One Photoacid Generators with Green/Red-light Responsiveness and Cooperative Functionality.

Photoacid generators (PAGs) are invaluable molecular tools that exhibited tremendous potential in emerging interdisciplinary researches of life-science, nanotechnology and smart materials. However, current PAGs are primarily mono-functional in terms of acid generation and rely on UV/deep-blue light excitation, posing a fundamental hurdle to their broader adoption. Developing cooperatively functioned PAGs with long-wavelength light responsiveness presents a formidable challenge due to the absence of suitable molecular scaffolds.