Publications by authors named "J D Close"
Background: Despite the promise wearable technology offers through detailed insight into mobility and fall risk, timely identification of high risk, assessment of risk severity, evaluation of clinical interventions, and potential to redefine the assessment of behaviours which influence health, they are not routinely used in clinical practice.
Objective: Establish consensus on how wearable technology can be applied to support clinical care for people aged 50 and over experiencing changes to mobility and/or who are at increased risk of falling.
Methods: A Delphi study was conducted among 17 hospital-based health professionals.
Image-based spatial transcriptomics platforms are powerful tools often used to identify cell populations and describe gene expression in intact tissue. Spatial experiments return large, high-dimension datasets and several open-source software packages are available to facilitate analysis and visualization. Spatial results are typically imperfect.
View Article and Find Full Text PDFBackground: There is increasing evidence to support collaborative care and proactive comprehensive geriatric assessment and management in a number of surgical specialties. Data are lacking in older people under the care of plastic surgeons. This before/after study evaluates the impact of the introduction of a shared care model between geriatric medicine and plastic surgery in an Australian metropolitan teaching hospital.
View Article and Find Full Text PDFArticle Synopsis
- BAP1 mutations lead to a loss of function affecting cell cycle and DNA repair, making patients potentially responsive to PARP inhibitors like niraparib.
- A phase II trial evaluated niraparib in patients with advanced tumors likely to have mBAP1 mutations, focusing on response rates, progression-free survival, and overall survival.
- Despite not meeting the primary efficacy goal, some clinical benefits were observed in patients with confirmed mBAP1 mutations, suggesting the need for further research.
Article Synopsis
- Evidence-based guidelines suggest that all older adults with hip fractures should receive oral nutrition supplements (ONS), but this study found that only 47.3% of hospitalized patients received them.
- The research involved 385 older adults aged 65 and older from 29 hospitals across two countries, highlighting that ONS was more commonly given to those identified as malnourished and those lacking preoperative assessments.
- The study concludes that a more structured approach is needed to ensure that all older adults, regardless of cognitive or nutritional status, receive ONS to improve recovery outcomes after hip fractures.