Publications by authors named "J D Champagne"
Messenger RNA (mRNA) translation is a tightly controlled process frequently deregulated in cancer. Key to this deregulation are transfer RNAs (tRNAs), whose expression, processing and post-transcriptional modifications are often altered in cancer to support cellular transformation. In conditions of limiting levels of amino acids, this deregulated control of protein synthesis leads to aberrant protein production in the form of ribosomal frameshifting or misincorporation of non-cognate amino acids.
View Article and Find Full Text PDFBackground: Intravenous immunoglobulin (IVIG) shortage represents an emerging issue in transfusion medicine. Limited data are available to determine effective strategies for optimal use. The objective of this retrospective observational study was to determine the impact of institutional measures on IVIG use at a large academic center.
View Article and Find Full Text PDFBackground The use of bendamustine with an anti-CD20 monoclonal antibody as frontline therapy for indolent non-Hodgkin lymphoma (NHL) has become a standard of care. We aimed to evaluate the real-world efficacy and safety of bendamustine-rituximab (BR) frontline therapy for indolent NHL. Patients and methods Patients with indolent NHL treated with frontline BR therapy in Hôpital du Sacré-Coeur de Montréal, from January 2015 to August 2018 were included in this retrospective study.
View Article and Find Full Text PDFAim: The diagnosis of hypertrophic cardiomyopathy (HCM) with moderate hypertrophy is challenging. Hypertensive heart disease (HHD) is the most common differential diagnosis that mimics the LVH of HCM. The aim of this study was to compare the QRS duration in HCM and HHD to create a novel diagnostic tool to identify primary HCM.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to evaluate the effectiveness of combining comparative genomic hybridization and single-nucleotide polymorphism (CGH/SNP) analyses for risk stratification in pediatric acute lymphoblastic leukemia (ALL) compared to traditional cytogenetic methods.
- - Researchers analyzed data from 135 patients aged 1-18 diagnosed with ALL, finding that CGH/SNP had a significantly lower failure rate and faster result turnaround (5.8 days) than conventional karyotyping (10.7 days).
- - CGH/SNP detected crucial gene deletions, particularly ETV6, which was associated with better event-free survival, indicating that CGH/SNP could enhance diagnostic accuracy and prognostic evaluation in pediatric ALL.