Publications by authors named "J D Bergeron"
Myelin's role in processing speed is pivotal, as it facilitates efficient neural conduction. Its decline could significantly affect cognitive efficiency during ageing. In this work, myelin content was quantified using our advanced MRI method of myelin water fraction mapping.
View Article and Find Full Text PDFBackground: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disease of low-density lipoprotein cholesterol (LDL-C) metabolism. Despite the devastating effect of this disease on atherosclerotic cardiovascular health, the disease phenotype and severity are more heterogeneous than previously thought. The predictors of atherosclerotic cardiovascular disease (ASCVD) in HoFH patients have never been systematically studied.
View Article and Find Full Text PDFBackground: Physical activity is essential for maintaining muscle mitochondrial function and aerobic capacity. The molecular mechanisms underlying such protective effects are incompletely understood, in part because it is difficult to separate the effects of disease status and physical activity. We explored the association of human skeletal muscle transcriptomic with four measures of energetics and mitochondria oxidative capacity in healthy individuals.
View Article and Find Full Text PDFArticle Synopsis
- Cystic fibrosis (CF) modulators have improved patient outcomes, but individual responses vary, especially regarding respiratory issues; the study explores the effects of ketone monoester (KME) on CF patients by boosting D-beta hydroxybutyrate concentrations and assessing quality of life and inflammation.
- Fourteen adults on modulator therapy were divided into two groups: one received KME and the other a placebo for 5-7 days while hospitalized or as outpatients; KME was well tolerated, showing significant increases in D-βHB levels and better self-reported respiratory scores compared to the placebo group.
- Although short-term KME administration didn’t significantly change plasma inflammatory markers, there were notable differences in
Background: Mortality prognostic tools exist to aid in shared decision making with kidney failure patients but are underutilized. This study aimed to elucidate nephrology providers' practice patterns and understand barriers to prognostic tool use.
Methods: Nephrology providers (8 physicians and 2 nurse practitioners) at an academic medical center underwent semi-structured interviews regarding their experience and perspective on the utility of mortality prognostic tools.