Publications by authors named "J D Beatty"
We disclose a stereodivergent strategy to prepare difluorinated tetralins from γ-substituted tetralones via a combination of catalyst-controlled transfer hydrogenation and substrate-controlled fluorinations. This process is easily scalable and amenable to highly functionalized substrates, as demonstrated here in the late-stage synthesis of casdatifan, a clinical-stage inhibitor of hypoxia-inducible factor-2α. Analysis of the physicochemical properties of casdatifan, which features a difluoride, revealed a higher level of facial polarization compared to its difluoride isomers.
View Article and Find Full Text PDFSurgical management of feline extra-hepatic biliary obstruction (EHBO) has poor survival rates with few prognostic factors reported in the literature. The etiology and clinical findings of feline EHBO and their influence on short-(2 weeks-6 months) and long-term (>6 months) survival and prognosis were examined in an observational clinical retrospective study of 26 client-owned cats undergoing surgery for biliary obstruction at one institution between 2012 and 2020. The etiology of EHBO was determined in 21/26 cats, which included inflammatory causes (14/21), neoplastic causes (6/21), and a duodenal foreign body (1/21).
View Article and Find Full Text PDFBackground: Benchmarking faculty workload is key for equity, but a standard model like the Carnegie Unit, originally designed for student workload, does not fit all scenarios.
Methods: A novel Faculty Effort Data Collection Tool assessed whether the Carnegie Unit accurately reflected faculty effort in a graduate nursing program. Workload was evaluated course-by-course based on faculty self-reported hours.
Article Synopsis
- * The study introduces enhanced modeling techniques for neutrino flux and detector response, and it distinguishes between starting (inside) and throughgoing (outside) neutrino interaction events to improve energy resolution.
- * The findings indicate a best-fit point for the 3+1 model with sin²(2θ_{24})=0.16 and Δm_{41}²=3.5 eV², supporting previous studies while showing consistency with no evidence of sterile neutrinos, as reflected
Individuals with a stronger sense of purpose in life experience better health across the lifespan. This chapter describes one mechanism linking purpose to health, namely stress reactivity. Across survey, experimental, and daily diary studies, research demonstrates that sense of purpose may yield a homeostatic function, insofar that it helps individuals stay the course to progress toward their purpose in life.
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