Publications by authors named "J D Barata"
J Clin Invest
October 2024
Article Synopsis
- Some babies with a specific mutation in the IL7R gene have a serious immune problem called SCID, where they lack a certain type of immune cells called T cells, but still have normal B and NK cells.
- In a study of 6 adults who have a similar genetic issue, they showed low levels of T cells but had relatively normal levels of other immune cells, indicating a more specific problem in T cell development.
- Even though their T cells didn’t grow well in the lab, the study hints that there might be another way T cells can develop that doesn’t depend solely on the IL-7 cytokine.
Article Synopsis
- Combining ATR inhibition with radiotherapy enhances the activation of specific T cells in head and neck squamous cell carcinoma (HNSCC) animal models.
- The addition of NKG2A and PD-L1 blockade to this combination leads to a stronger antitumor response by increasing the presence of activated cytotoxic T cells in tumors.
- The effectiveness of this treatment relies on specific immune signaling and the diversity of T cell receptors, suggesting promising new strategies for HNSCC therapy.
Article Synopsis
- γδ T cells play a crucial role in immune responses by quickly producing interferon-γ (IFN-γ), especially during the perinatal period when there's an increase in these cells that express CD8αβ heterodimers.
- Their development relies on low T cell receptor signaling, supported by interleukin (IL)-4 and IL-7, which helps regulate their growth.
- Aberrations in IL-7R-STAT5B signaling can lead to an excessive number of these cells in certain diseases, and they are also linked to pediatric cases of acute lymphoblastic leukemia.
