Improving the Infrastructure for Pediatric Medical Device Trials at Children's Hospitals.

The shortage of novel pediatric devices that accommodate the unique needs of children exists due to several scientific, clinical, regulatory, and financial barriers. This global unmet need is being addressed in the United States by multiple stakeholders including the Food and Drug Administration (FDA) and its Pediatric Device Consortia (PDC) grant program. One critical area of interest is the suboptimal medical device clinical trial infrastructure that currently exists in academic medical centers and compounded at children's hospitals.

Rehabilitation Perspectives in Spinal Cord Ischemia After Major Vascular Surgery: A Case Series.

Objectives: This observational study aims to summarize the disability profile, rehabilitation strategies, and six-month outcomes in patients with Spinal Cord Ischemia (SC-ischemia) following Major Vascular Surgeries (MVS) at our institution.

Methods: Retrospective data were collected from seven patients who underwent MVS between April 2016 and March 2020.

Results: All patients were male, with a mean age of 68.

Volatile Cues from Fresh Cattle Dung Can Drive Horn Fly Egg-Laying and Fecal Attraction to Horn Flies, (Diptera: Muscidae).

The horn fly is an economically important hematophagous ectoparasite of cattle. Its management relies heavily on broad-spectrum pesticides, which are harmful to the environment and have led to the development of resistance. Therefore, alternative control methods are needed.

The Evolving Landscape in Multiple Myeloma: From Risk Stratification to T Cell-Directed Advanced Therapies.

Multiple myeloma is biologically and clinically a complex and heterogeneous disease which develops late in life, with the median age at the time of initial diagnosis being 66 years. In 1975, Durie and Salmon developed the first broadly adopted staging system in multiple myeloma, and in the ensuing decades, the risk stratification tools have improved and now incorporate different parameters to better predict the prognosis and to guide the treatment decisions. The International Staging System (ISS) was initially developed in 2005, revised in 2015 (R-ISS), and again in 2022 (R2-ISS).