The generation of stable microvessels in ischemia is mediated by endothelial cell derived TRAIL.

Reversal of ischemia is mediated by neo-angiogenesis requiring endothelial cell (EC) and pericyte interactions to form stable microvascular networks. We describe an unrecognized role for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in potentiating neo-angiogenesis and vessel stabilization. We show that the endothelium is a major source of TRAIL in the healthy circulation compromised in peripheral artery disease (PAD).

Sex, Endothelial Cell Functions, and Peripheral Artery Disease.

Peripheral artery disease (PAD) is caused by blocked arteries due to atherosclerosis and/or thrombosis which reduce blood flow to the lower limbs. It results in major morbidity, including ischemic limb, claudication, and amputation, with patients also suffering a heightened risk of heart attack, stroke, and death. Recent studies suggest women have a higher prevalence of PAD than men, and with worse outcomes after intervention.

A hidden problem: peripheral artery disease in women.

Peripheral artery disease (PAD) has a huge social and economic burden and is an important contributor to the global health burden. Sex differences in PAD are apparent, with recent data suggesting equal if not greater prevalence in women, and women having worse clinical outcomes. Why this occurs is not clear.

Colorimetric Detection of Metals Using CdS-NPs Synthesized by an Organic Extract of Aspergillus niger.

The use of cadmium sulfide nanoparticles (CdS-NPs) synthesized by fungi presents highly stable chemical and optical characteristics; this makes them a promising alternative for development of colorimetric methods for metal detection. Moreover, application of CdS-NPs is challenging due to the biological material used to carry out synthesis and coating is highly diverse; therefore, it is necessary to evaluate if such components are present in the biological material. Thus, the objective of this work was to detect metallic ions in synthetic water samples using CdS-NPs synthesized by the extract of Aspergillus niger.