Publications by authors named "J Crossley"
The ATP-independent chaperone SurA protects unfolded outer membrane proteins (OMPs) from aggregation in the periplasm of Gram-negative bacteria, and delivers them to the β-barrel assembly machinery (BAM) for folding into the outer membrane (OM). Precisely how SurA recognises and binds its different OMP clients remains unclear. Escherichia coli SurA comprises three domains: a core and two PPIase domains (P1 and P2).
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- * Research by Hillman et al. (2013) argued that previous studies have mainly focused on mammals, suggesting that non-mammalian vertebrates have evolved excess capacity in their cardiorespiratory systems to improve CO2 removal.
- * In our study on American alligators, we found that their cardiorespiratory system effectively supports CO2 excretion during intense exercise, showing no significant limitations in how they expel carbon dioxide.
Three cases of uncommon medication-associated osteonecrosis of temporal bone.
World J Otorhinolaryngol Head Neck Surg
September 2024
Article Synopsis
- Medication-related osteonecrosis of the temporal bone is uncommon and linked to certain medications, specifically anti-resorptive and tyrosine-kinase inhibitors, with new cases being reported.* -
- Three case studies highlight patients with osteonecrosis of the external auditory canal (EAC), with treatments ranging from conservative management to surgical reconstruction, showing varying success.* -
- The findings suggest that these medications can disrupt bone remodeling, and when standard therapies fail, surgical intervention may be necessary for symptom relief.*
The outer membrane is a formidable barrier that protects Gram-negative bacteria against environmental threats. Its integrity requires the correct folding and insertion of outer membrane proteins (OMPs) by the membrane-embedded β-barrel assembly machinery (BAM). Unfolded OMPs are delivered to BAM by the periplasmic chaperone SurA, but how SurA and BAM work together to ensure successful OMP delivery and folding remains unclear.
View Article and Find Full Text PDFTemperature effects on blood gases in embryonic American alligators (Alligator mississippiensis).
Comp Biochem Physiol A Mol Integr Physiol
November 2024
Numerous studies report on the influence of temperature on blood gases in ectothermic vertebrates, but there is merely a cursory understanding of these effects in developing animals. Animals that develop in eggs are at the mercy of environmental temperature and are expected to lack the capacity to regulate gas exchange and may regulate blood gases by means of altered conductance for gas exchange. We, therefore, devised a series of studies to characterize the developmental changes in blood gases when embryonic alligators were exposed to 25, 30 and 35 °C.
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