Publications by authors named "J Croft"
Humans sometimes synchronize their steps to mechanical oscillations in the environment (e.g., when walking on a swaying bridge or with a wearable robot).
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- Ileus, a common issue post-surgery leading to gastrointestinal problems, shows potential for improvement through non-invasive vagus nerve stimulation (nVNS), which may reduce inflammation and enhance gut function.
- A multicentric trial involving 97 colorectal surgery patients assessed the feasibility of self-administered nVNS compared to a sham treatment, focusing on recruitment, compliance, and clinical outcomes over 30 days.
- While initial results indicated no significant difference in gut recovery times between the two groups, patient motivation and interest in nVNS suggest the need for further powered trials to evaluate its effectiveness definitively.
Cerebral cavernous malformations (CCMs) are abnormal expansions of brain capillaries that increase the risk of hemorrhagic strokes, with CCM1 mutations responsible for about 50% of familial cases. The disorder can cause irreversible brain damage by compromising the blood-brain barrier (BBB), leading to fatal brain hemorrhages. Studies show that progesterone and its derivatives significantly impact BBB integrity.
View Article and Find Full Text PDFBackground: The number of surgical trials is increasing but such trials can be complex to deliver and pose specific challenges. A multi-centre, Phase III, RCT comparing Posterior Cervical Foraminotomy versus Anterior Cervical Discectomy and Fusion in the Treatment of Cervical Brachialgia (FORVAD Trial) was unable to recruit to target. A rapid qualitative study was conducted during trial closedown to understand the experiences of healthcare professionals who participated in the FORVAD Trial, with the aim of informing future research in this area.
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