Publications by authors named "J Crew"
Apical extracellular matrices (aECMs) are complex extracellular compartments that form important interfaces between animals and their environment. In the adult C. elegans cuticle, layers are connected by regularly spaced columnar structures known as struts.
View Article and Find Full Text PDFInsufficient tracking of virus introduction, spread, and new lineage emergence for the human monkeypox (mpox) virus 1 (hMPXV1) outbreak of 2022 hindered epidemiological studies and public health response. hMPXV1 mutations accumulated unexpectedly faster than predicted. Thus, new variants with altered pathogenicity could emerge and spread without early detection.
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- This study examined the safety and tolerability of the anti-PD-1 drug pembrolizumab in patients with non-muscle-invasive bladder cancer (NMIBC) following bladder tumor removal surgery (TURBT).
- Six patients received intravesical pembrolizumab in increasing doses (50 mg to 200 mg) without significant safety issues or dose-limiting toxicities.
- The treatment was well-tolerated with mild side effects and no signs of systemic absorption or immune system changes, suggesting further research is needed to evaluate the potential benefits of this administration method.