Publications by authors named "J Creteur"
Article Synopsis
- The study investigated the use of alteplase thrombolysis in patients with severe hypoxemic respiratory failure caused by COVID-19, comparing it to standard care (SOC) alone.
- Results showed that patients receiving alteplase experienced a median time to clinical improvement of 25 days compared to more than 28 days for those on SOC, along with a lower mortality rate (12% vs. 29%).
- However, 26.1% of the alteplase group had to stop treatment due to adverse effects, and major bleeding incidents were more common in the alteplase group, although no fatalities occurred.
Article Synopsis
- The study aimed to investigate changes in the renin-angiotensin system during septic shock, particularly looking at ACE activity and the levels of different angiotensin peptides using mass spectrometry.
- Experimental septic shock was induced in pigs, with further interventions like fluid resuscitation and antibiotics, while monitoring various time points.
- Results showed increased renin and angiotensin levels, decreased ACE activity, and a shift towards the angiotensin-(1-7) axis, indicating possible adaptive responses within the RAS that could inform future sepsis treatments.
Article Synopsis
- Cerebral complications following cardiac arrest (CA) pose significant challenges globally, prompting research on sodium-ß-hydroxybutyrate (SBHB) as a potential treatment for brain injury in a swine model.
- In an experiment with 20 adult swine, CA was induced, followed by 5 minutes of resuscitation, after which animals received either SBHB infusion or a control solution for 12 hours.
- Results showed that SBHB infusion led to lower plasma biomarkers of brain injury and increased sEEG amplitude, indicating potential protective effects against cerebral damage after resuscitation.
The importance of perfusion-guided resuscitation in septic shock has recently emerged. We explored whether the use of hemoadsorption led to a potential beneficial role in microvascular alterations in this clinical setting. : A pre-planned secondary analysis of a Phase-II interventional single-arm pilot study (NCT05658588) was carried out, where 17 consecutive septic shock children admitted into PICU were treated with continuous renal replacement therapy (CRRT) and CytoSorb.
View Article and Find Full Text PDFObjectives: To assess microvascular reactivity during a skin thermal challenge early post-cardiac surgery and its association with outcomes.
Design: Noninvasive physiological study.
Setting: Thirty-five-bed department of intensive care.