Publications by authors named "J Craig Moffat"
During gastrulation, Wnt-β-catenin signaling dictates lineage bifurcation generating different mesoderm cell types. However, the specific role of Wnt receptors in mesoderm specification remains elusive. Using selective Frizzled (FZD) and LRP5/6 antibody-based agonists, we examined FZD receptors' function during directed mesoderm differentiation of human pluripotent stem cells (hPSCs).
View Article and Find Full Text PDFCancer-intrinsic immune evasion mechanisms and pleiotropy are a barrier to cancer immunotherapy. This is apparent in certain highly fatal cancers, including high-grade gliomas and glioblastomas (GBM). In this study, we evaluated two murine syngeneic glioma models (GL261 and CT2A) as preclinical models for human GBM using functional genetic screens, single-cell transcriptomics and machine learning approaches.
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- * The conference addressed a broad range of topics in antiviral science, including new antiviral drugs, vaccines, clinical trials, and strategies to tackle emerging viral threats.
- * Keynote talks highlighted important issues like virus emergence in human-animal interactions and challenges in developing effective antivirals, with a summary provided for ICAR 2024 and a preview for the upcoming ICAR 2025 in Las Vegas.
Precision gene editing enables massively parallel identification of cancer-promoting genes.
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