Modified T-cell activation pattern during specific immunotherapy (SIT) in cat-allergic patients.

Objective: The aim of the study was to analyse early effects of specific immunotherapy (SIT) on immune functions in cat-allergic patients.

Methods: Immunological responses of peripheral blood mononuclear cells from eight cat-allergic patients were analysed before and after SIT in comparison with 11 nonallergic controls. Cells were stimulated in vitro with either bacterial superantigen, mitogen, or cat allergen.