Publications by authors named "J Courjon"
Background: Bacteremia is a common complication in allogeneic hematopoietic cell transplant recipients (alloHCTr), especially during the pre-engraftment period. International guidelines recommend antibacterial prophylaxis (ABP), despite potential selection for multidrug-resistant organisms (MDRO). Limited contemporary data exist on the epidemiology of pre-engraftment bacteremia in alloHCTr, who do not receive ABP.
View Article and Find Full Text PDFA growing number of patients presenting severe combined immunodeficiencies attributed to monoallelic RAC2 variants have been identified. The expression of the RHO GTPase RAC2 is restricted to the hematopoietic lineage. RAC2 variants have been described to cause immunodeficiencies associated with high frequency of infection, leukopenia, and autoinflammatory features.
View Article and Find Full Text PDFArticle Synopsis
- The study examines current practices with long half-life lipoglycopeptides (LGPs), particularly oritavancin, and how they're mainly used off-label for bone and joint infections (BJIs) and infective endocarditis despite being approved only for skin and soft tissue infections (SSTIs).
- Oritavancin, along with dalbavancin, is notable for its one-time dosing, with oritavancin potentially offering advantages for shorter treatment durations (less than 2 weeks) and various infections like urinary tract infections and catheter-related infections.
- The findings suggest that LGPs, such as oritavancin, are changing treatment approaches for acute bacterial infections and may
Background: The 4th European Conference on Infections in Leukemia recommends early adaptation of empirical antibiotic therapy (EAT) for febrile neutropenia in stable patients.
Objectives: To assess the efficacy of an antimicrobial stewardship (AMS) intervention promoting early de-escalation and discontinuation of EAT in high-risk neutropenic patients.
Methods: This before-after study was conducted in the hematology department of the University Hospital of Nice, France.