The decline of antibiotics efficacy worldwide has recently reached a critical point urging for the development of new strategies to regain upper hand on multidrug resistant bacterial strains. In this context, the raise of photodynamic therapy (PDT), initially based on organic photosensitizers (PS) and more recently on organometallic PS, offers promising perspectives. Many PS exert their biological effects through the generation of reactive oxygen species (ROS) able to freely diffuse into and to kill surrounding bacteria.
View Article and Find Full Text PDFEur J Clin Microbiol Infect Dis
March 2023
This study was set up to assess the performance of the Reveal® rapid AST system to determine the drug susceptibility of Pseudomonas aeruginosa strains directly from blood cultures. Two hundred fully sequenced clinical P. aeruginosa strains were selected for the evaluation, of which 26.
View Article and Find Full Text PDFThis paper investigates the problem of forecasting multivariate aggregated human mobility while preserving the privacy of the individuals concerned. Differential privacy, a state-of-the-art formal notion, has been used as the privacy guarantee in two different and independent steps when training deep learning models. On one hand, we considered , which uses the differentially private stochastic gradient descent algorithm to guarantee the privacy of each time series sample in the learning stage.
View Article and Find Full Text PDFthat are present in the rivers are mostly brought by human and animal feces. Contamination occurs mostly through wastewater treatment plant (WWTP) outflows and field amendment with sewage sludge or manure. However, the survival of these isolates in river-associated wetlands remains unknown.
View Article and Find Full Text PDFIn this article, we propose a semi-automated method to rebuild genome ancestors of chloroplasts by taking into account gene duplication. Two methods have been used in order to achieve this work: a naked eye investigation using homemade scripts, whose results are considered as a basis of knowledge, and a dynamic programming based approach similar to Needleman-Wunsch. The latter fundamentally uses the Gestalt pattern matching method of sequence matcher to evaluate the occurrences probability of each gene in the last common ancestor of two given genomes.
View Article and Find Full Text PDF