Publications by authors named "J Costas"
Genomic evidence of GLP-1 receptor as target for the treatment of substance use disorders.
Eur Neuropsychopharmacol
December 2024
Article Synopsis
- - The study investigates the role of the Pyk2 gene in obesity among children and adolescents, noting its previously unclear involvement in energy balance-related diseases.
- - Researchers measured mRNA expression levels of Pyk2 in 130 Caucasian subjects, split into two groups based on Body Mass Index (BMI), and found higher expression levels in those with obesity.
- - The results revealed a positive correlation between Pyk2 expression levels and various obesity-related metrics (like weight, fat mass, and blood pressure), suggesting that Pyk2 may be a potential predictor for developing obesity.
Shared polygenic susceptibility to treatment response in severe affective and psychotic disorders: Evidence from GWAS data sets.
Prog Neuropsychopharmacol Biol Psychiatry
October 2024
Article Synopsis
- The study investigates the genetic links between treatment-resistant schizophrenia (TRS), lithium response in bipolar disorder (BD), and antidepressant response in major depressive disorder (MDD).
- It employs the conditional/conjunctional false discovery rate (cond/conjFDR) methodology to identify shared genetic mechanisms that might influence treatment outcomes across these disorders.
- The findings suggest a significant genetic correlation, particularly highlighting the MAP2K1 gene as a shared locus, and indicate a need for future research with larger data sets to validate these results.
Identification of gene co-expression modules from zebrafish brain data: Applications in psychiatry illustrated through alcohol-related traits.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
Cumulative evidence suggests that zebrafish is a useful model in psychiatric research. Weighted Gene Co-expression Network Analysis (WGCNA) enables the reduction of genome-wide expression data to modules of highly co-expressed genes, which are hypothesized to interact within molecular networks. In this study, we first applied WGCNA to zebrafish brain expression data across different experimental conditions.
View Article and Find Full Text PDFBackground: Epidemiological studies have linked low birth weight to psychiatric disorders, including substance use disorders. Genomic analyses suggest a role of placental physiology on psychiatric risk. We investigated whether this association is causally related to impaired trophoblast function.
View Article and Find Full Text PDF