Publications by authors named "J Cordoba-Chacon"
Pancreatic ductal adenocarcinoma (PDAC) is one of the worst solid malignancies in regard to outcomes and metabolic dysfunction leading to cachexia. It is alarming that PDAC incidence rates continue to increase and warrant the need for innovative approaches to combat this disease. Due to its relatively slow progression (10-20 years), prevention strategies represent an effective means to improve outcomes.
View Article and Find Full Text PDFMetabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic liver condition that often progresses to more advanced stages, such as metabolic dysfunction-associated steatohepatitis (MASH). MASH is characterized by inflammation and hepatocellular ballooning, in addition to hepatic steatosis. Despite the relatively high incidence of MASH in the population and its potential detrimental effects on human health, this liver disease is still not fully understood from a pathophysiological perspective.
View Article and Find Full Text PDFArticle Synopsis
- Growth hormone (GH) influences liver gene transcription differently in males and females, which is important for liver metabolism related to sex, and dysregulation of GH can lead to liver diseases that affect each sex differently.
- Researchers examined how GH affects specific genes associated with metabolism, using various mouse models with altered GH levels and liver GH receptor (GHR) presence, to see its impact on male- and female-predominant genes.
- Findings revealed sex-specific gene expression changes due to GH and GHR manipulation, indicating that GH regulates distinct gene signatures in males and females, suggesting a complex relationship between GH action and liver health based on sex.
Short-chain fatty acids (SCFAs) are key nutrients that play a diverse set of roles in physiological function, including regulating metabolic homeostasis. Generated through the fermentation of dietary fibers in the distal colon by the gut microbiome, SCFAs and their effects are partially mediated by their cognate receptors, including free fatty acid receptor 2 (FFA2). FFA2 is highly expressed in the intestinal epithelial cells, where its putative functions are controversial, with numerous in vivo studies relying on global knockout mouse models to characterize intestine-specific roles of the receptor.
View Article and Find Full Text PDFBackground & Aims: Dysbiosis contributes to alcohol-associated liver disease (ALD); however, the precise mechanisms remain elusive. Given the critical role of the gut microbiota in ammonia production, we herein aim to investigate whether and how gut-derived ammonia contributes to ALD.
Methods: Blood samples were collected from human subjects with/without alcohol drinking.