Real world outcomes of biopsy-proven oncocytic neoplasm of the kidney managed by surveillance.

Objectives: To evaluate outcomes of patients diagnosed with oncocytic renal neoplasms on routine renal mass biopsy and to describe the natural history of these tumours when managed with surveillance as opposed to immediate intervention. To report disease-specific survival.

Patients And Methods: Patients were identified from a retrospective review of pathology databases from three tertiary referral centres that utilise renal mass biopsy in routine clinical practice.

Risk factors for incident delirium among urological patients: a systematic review and meta-analysis with GRADE summary of findings.

Background: Post-operative delirium is an important, yet under-researched complication of surgery. Patients undergoing urological surgery may be at especially high risk of POD, as they are often older, and interventions can be associated with conditions that trigger delirium. The main aim of this systematic review was to evaluate the available evidence for risk factors in this patient group.

Single centre versus multi-centre pooled morbidity data in PCNL and the implications for informed consent.

National and international outcome data following PCNL have been available for many years, but multi-centre data may not reflect the outcome from an individual surgeon or hospital. A combination of retrospective and prospective single centre data was collated from 2000-2016 and are compared to large single and multi-centre series. Data were available on 801 unique cases performed between 2000 and 2016, mean age = 55.

Accumulation of Dietary S-Methyl Cysteine Sulfoxide in Human Prostate Tissue.

Scope: Observational studies have associated consumption of cruciferous vegetables with reduced risk of prostate cancer. This effect has been associated with the degradation products of glucosinolates-thioglycosides that accumulate within crucifers. The possible role of S-methyl cysteine sulfoxide, a metabolite that also accumulates in cruciferous vegetables, and its derivatives, in cancer prevention is relatively unexplored compared to glucosinolate derivatives.

An LC-MS/MS Method to Measure -Methyl-l-Cysteine and -Methyl-l-Cysteine Sulfoxide in Human Specimens Using Isotope Labelled Internal Standards.

This is the first report describing an analytical method for quantitative analysis of two naturally occurring sulphur compounds, -methyl-l-cysteine (SMC) and -methyl-l-cysteine sulfoxide (SMCSO), in human body fluids using isotope-labelled internal standards and liquid chromatography-mass spectrometry (LC-MS)/MS techniques. This method was validated according to the guideline of the Royal Society of Chemistry Analytical Methods Committee. It offers significant advantages including simple and fast preparation of human biological samples.