Publications by authors named "J Compte"
Article Synopsis
- A major challenge in treating neurodegenerative diseases is the lack of accurate models that simulate human disease processes, particularly concerning neuromelanin accumulation with aging.
- Researchers developed a transgenic mouse model, tgNM, that mimics the distribution of neuromelanin in human brains, specifically in catecholamine-producing neurons.
- This model exhibits age-related neuronal dysfunction and degeneration, presenting symptoms similar to early stages of neurodegenerative diseases, thus offering new opportunities for research in brain aging and neurodegeneration.
Article Synopsis
- Aging humans accumulate neuromelanin, a pigment linked to degeneration of dopaminergic neurons, particularly in Parkinson's disease, which is not seen in most animals.
- Researchers created humanized rodents that produce neuromelanin to study its effects, finding that excessive accumulation can trigger Parkinson's pathology.
- By manipulating dopamine storage in these rodents, they were able to reduce neuromelanin production, leading to improved neuronal health and motor function, suggesting a potential therapeutic approach for Parkinson's and age-related brain issues.
Validation of a Reversed Phase UPLC-MS/MS Method to Determine Dopamine Metabolites and Oxidation Intermediates in Neuronal Differentiated SH-SY5Y Cells and Brain Tissue.
ACS Chem Neurosci
September 2020
Article Synopsis
- Dopamine plays a crucial role in neurological disorders like addiction and Parkinson's disease, with disturbances in its metabolism potentially leading to toxic effects.
- A new UPLC-MS/MS method has been developed to detect and quantify eight dopamine-related metabolites, including aminochrome, in various biological samples.
- The study validates the method's effectiveness on different tissues and demonstrates its application in understanding metabolic changes associated with dopamine and neuromelanin production in Parkinson's disease.
Background: The relationship between the gut microbiome and the human host is dynamic and we may expect adjustments in microbiome function if host physiology changes. Metatranscriptomic approaches should be key in unraveling how such adjustments occur.
Methods: We employ metatranscriptomic sequencing analyses to study gene expression in the gut microbiota of infants through their first year of life, and of their mothers days before delivery and one year afterwards.
Assuming that dispersal modes or abilities can explain the different responses of organisms to geographic or environmental distances, the distance-decay relationship is a useful tool to evaluate the relative role of local environmental structuring versus regional control in community composition. Based on continuing the current theoretical framework on metacommunity dynamics and based on the predictive effect of distance on community similarity, we proposed a new framework that includes the effect of spatial extent. In addition, we tested the validity of our proposal by studying the community similarity among three biotic groups with different dispersal modes (macrofaunal active and passive dispersers and plants) from two pond networks, where one network had a small spatial extent, and the other network had an extent that was 4 times larger.
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