Publications by authors named "J Colnot"
Background And Purpose: FLASH or ultra-high dose rate (UHDR) radiation therapy (RT) has gained attention in recent years for its ability to spare normal tissues relative to conventional dose rate (CDR) RT in various preclinical trials. However, clinical implementation of this promising treatment option has been limited because of the lack of availability of accelerators capable of delivering UHDR RT. Commercial options are finally reaching the market that produce electron beams with average dose rates of up to 1000 Gy/s.
View Article and Find Full Text PDFBackground & Purpose: FLASH or ultra-high dose rate (UHDR) radiation therapy (RT) has gained attention in recent years for its ability to spare normal tissues relative to conventional dose rate (CDR) RT in various preclinical trials. However, clinical implementation of this promising treatment option has been limited because of the lack of availability of accelerators capable of delivering UHDR RT. Commercial options are finally reaching the market that produce electron beams with average dose rates of up to 1000 Gy/s.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the out-of-field dose delivered during external photon beam radiation therapy, as it may lead to a higher risk of second cancers and affect immune system efficiency in radio-immunotherapy treatments.
- Traditional methods for estimating out-of-field doses are complex and not suitable for clinical use, prompting the exploration of deep learning techniques for more effective dose map prediction.
- A 3D U-Net model, trained on data from 3,151 pediatric patients, demonstrated promising results in estimating out-of-field doses, achieving low error rates in both training and validation, indicating potential for clinical application.
A growing body of scientific evidence indicates that exposure to low dose ionizing radiation (< 2 Gy) is associated with a higher risk of developing radio-induced cancer. Additionally, it has been shown to have significant impacts on both innate and adaptive immune responses. As a result, the evaluation of the low doses inevitably delivered outside the treatment fields (out-of-field dose) in photon radiotherapy is a topic that is regaining interest at a pivotal moment in radiotherapy.
View Article and Find Full Text PDFPurpose: First, this experimental study aims at comparing out-of-field doses delivered by three radiotherapy techniques (3DCRT, VMAT (two different accelerators), and tomotherapy) for a pediatric renal treatment. Secondly, the accuracy of treatment planning systems (TPS) for out-of-field calculation is evaluated.
Methods: EBT3 films were positioned in pediatric phantoms (5 and 10 yr old).