Propensity Score Analysis of Possible Medication Effects on Outcomes in Patients With Systemic Right Ventricles.

Background: Patients with systemic right ventricle (SRV), either d-transposition of the great arteries following an atrial switch procedure or congenitally corrected transposition of the great arteries, develop severe right ventricular dysfunction, prompting appropriate medical therapy. However, the efficacy of beta-blockers and angiotensin receptor blockers or angiotensin-converting enzyme inhibitors (ACEI) in SRV patients is unproven.

Objectives: The objective of this study was to determine the effects of ACEI/ARB and beta-blockers on outcomes in SRV patients after accounting for likely cofounders affecting their use.

Distilling the Evolving Contributions of Anthropogenic Aerosols and Greenhouse Gases to Large-Scale Low-Frequency Surface Ocean Changes Over the Past Century.

Anthropogenic aerosols (AER) and greenhouse gases (GHG)-the leading drivers of the forced historical change-produce different large-scale climate response patterns, with correlations trending from negative to positive over the past century. To understand what caused the time-evolving comparison between GHG and AER response patterns, we apply a low-frequency component analysis to historical surface ocean changes from CESM1 single-forcing large-ensemble simulations. While GHG response is characterized by its first leading mode, AER response consists of two distinct modes.

Combining tissue biomarkers with mpMRI to diagnose clinically significant prostate cancer. Analysis of 21 biomarkers in the PICTURE study.

Background: Serum PSA and digital rectal examination remain the key diagnostic tools for detecting prostate cancer. However, due to the limited specificity of serum PSA, the applicability of this marker continues to be controversial. Recent use of image-guided biopsy along with pathological assessment and the use of biomarkers has dramatically improved the diagnosis of clinically significant cancer.