Publications by authors named "J Clinton"
Elephant endotheliotropic herpesvirus (EEHV) causes lethal hemorrhagic disease (HD) in Asian and African elephants in human care and the wild. It is the leading cause of death for young Asian elephants in North American and European zoos despite sensitive diagnostic tests and improved treatments. Thus, there is a critical need to develop an effective vaccine to prevent severe illness and reduce mortality from EEHV-HD.
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- The study investigates how the immune system of young macaques can produce antibodies that neutralize various strains of HIV-1, showing a higher success rate in infants compared to adults.
- Over a 24-month period, 64% of young macaques developed these antibodies, linked to a healthier immune profile with reduced immunosuppressive factors.
- The findings suggest that understanding pediatric immune responses to SHIV may help in creating vaccines to protect infants and children from HIV-1 before they are exposed to the virus.
The number density of impact craters on a planetary surface is used to determine its age, which requires a model for the production rate of craters of different sizes. On Mars, however, estimates of the production rate of small craters (<60 m) from orbital imagery and from extrapolation of lunar impact data do not match. Here we provide a new independent estimate of the impact rate by analysing the seismic events recorded by the seismometer onboard NASA's InSight lander.
View Article and Find Full Text PDFSmooth muscle cell-specific myosin heavy chain, encoded by , is selectively expressed in smooth muscle cells (s). Pathogenic variants in predispose to a number of disorders, including heritable thoracic aortic disease associated with patent ductus arteriosus, visceral myopathy, and megacystis-microcolon-intestinal hypoperistalsis syndrome. Rare variants of uncertain significance occur throughout the gene, including p.
View Article and Find Full Text PDFBackground & Aims: Noninvasive variceal risk stratification systems have not been validated in patients with hepatocellular carcinoma (HCC), which presents logistical barriers for patients in the setting of systemic HCC therapy. We aimed to develop and validate a noninvasive algorithm for the prediction of varices in patients with unresectable HCC.
Methods: We performed a retrospective cohort study in 21 centers in the United States including adult patients with unresectable HCC and Child-Pugh A5-B7 cirrhosis diagnosed between 2007 and 2019.