Publications by authors named "J Clay Pruett"

Background: For metastatic and certain advanced prostate cancer (PC), guidelines support intensified androgen deprivation therapy (ADT) as first-line (1L) systemic treatment for improved outcomes. However, some patients receive ADT alone, leading to tumor progression requiring 2nd line therapy. Despite significant racial disparities in PC outcomes, there are no population-level studies assessing racial differences in time to subsequent treatment after 1L ADT.

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Background: Autism spectrum disorder (ASD), a neurodevelopmental disorder defined by social communication deficits plus repetitive behaviors and restricted interests, currently affects 1/36 children in the general population. Recent advances in functional brain imaging show promise to provide useful biomarkers of ASD diagnostic likelihood, behavioral trait severity, and even response to therapeutic intervention. However, current gold-standard neuroimaging methods (e.

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Article Synopsis
  • The study aimed to evaluate the effects of refractive surgery on the social functioning and vision-specific quality of life (VSQOL) in children with autism spectrum disorder and/or intellectual disabilities who struggle with wearing glasses or contact lenses.
  • 18 children participated in the surgery, and improvements were measured through standardized scales (SRS-2 and PedEyeQ) at various intervals post-surgery.
  • Results showed notable enhancements in social awareness, motivation, functional vision, and a reduction in vision-related bother after 12 months, indicating that refractive surgery can positively impact both social skills and quality of life for this population.
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Brain differences linked to autism spectrum disorder (ASD) can manifest before observable symptoms. Studying these early neural precursors in larger and more diverse cohorts is crucial for advancing our understanding of developmental pathways and potentially facilitating earlier identification. EEG is an ideal tool for investigating early neural differences in ASD, given its scalability and high tolerability in infant populations.

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Background: Emerging biomarker technologies (e.g., MRI, EEG, digital phenotyping, eye-tracking) have potential to move the identification of autism into the first year of life.

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