Publications by authors named "J Ciudad Bautista"
Background And Objectives: Apheresis platelets products and plasma are essential for medical interventions, but both still have inherent risks associated with contamination and viral transmission. Platelet products are vulnerable to bacterial contamination due to storage conditions, while plasma requires extensive screening to minimize virus transmission risks. Here we investigate rapid irradiation to sterilizing doses for bacteria and viruses as an innovative pathogen reduction technology.
View Article and Find Full Text PDFActinobacteriophage Magritte was isolated from soil in Columbia, TN using as a host. Magritte is a singleton with a siphovirus morphology and a large genome of 133,228 bp encoding 250 predicted genes, including 26 tRNA genes.
View Article and Find Full Text PDFCharacterization of species distributions is a fundamental challenge in biodiversity science, with particular significance for downstream evolutionary studies, conservation efforts, field-based faunal studies and estimates of species diversity. Checklists and phylogenetic studies often focus on poorly known, rare taxa with limited ranges. However, studies of widely distributed, ecologically important species that are abundant in their preferred microhabitats are also important for systematics and local conservation efforts, but less often studied.
View Article and Find Full Text PDFMultiple myeloma and the potential of new checkpoint inhibitors for immunotherapy.
Ther Adv Vaccines Immunother
October 2024
Article Synopsis
- Multiple myeloma (MM) is the second most common blood cancer in adults, but immunotherapy for MM has not been effective until recently.
- Recent studies on immune checkpoint inhibitors have shown that they often cause severe side effects or have low effectiveness, particularly in patients with advanced MM.
- The review discusses five inhibitory molecules involved in the immune response to MM and explores their roles in the tumor microenvironment and recent clinical trials involving these potential therapeutic targets.
Background: The function of mucosal secretory IgA (SIgA) seems to be paramount in the immune response against SARS-CoV-2 however, there are few studies addressing this issue specifically in the institutionalized older population. This study aims to determine the levels of secretory IgA against the S1 domain of the SARS-CoV-2 spike (SIgA-S1) in older people living in nursing homes (NH) and to investigate the differences in baseline characteristics, severity of COVID-19, duration of symptoms, 30-day mortality, and reinfection according to the levels of SIgA-S1.
Methods: In this multicentre longitudinal study, conducted in two NHs attended in coordination with a hospital-based Geriatric team, 305 residents (87.