Venous Endothelial Cell Transcriptomic Profiling Implicates METAP1 in Preeclampsia.

Background: Preeclampsia is a hypertensive disorder of pregnancy characterized by systemic endothelial dysfunction. The pathophysiology of preeclampsia remains incompletely understood. This study used human venous endothelial cell (EC) transcriptional profiling to investigate potential novel mechanisms underlying EC dysfunction in preeclampsia.

Expansion microscopy reveals neural circuit organization in genetic animal models.

Expansion microscopy is a super-resolution technique in which physically enlarging the samples in an isotropic manner increases inter-molecular distances such that nano-scale structures can be resolved using light microscopy. This is particularly useful in neuroscience as many important structures are smaller than the diffraction limit. Since its invention in 2015, a variety of expansion microscopy protocols have been generated and applied to advance knowledge in many prominent organisms in neuroscience, including zebrafish, mice, , and .

Restoring Mitochondrial Quantity and Quality to Reverse Warburg Effect and Drive Tumor Differentiation.

Reduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors, and whether mitochondrial restoration can drive tumor differentiation. Our study shows that restoring mitochondrial function using retinoic acid (RA) to boost mitochondrial biogenesis and a mitochondrial uncoupler to enhance respiration synergistically drives neuroblastoma differentiation and inhibits proliferation.

A Modified Delphi Process to Achieve Consensus on Social/Administrative Science Topics in Pharmacy Curricula.

Objective: To identify a consensus among pharmacy educators regarding relevant social/administrative science (SAS) topic areas and their priorities within pharmacy curricula.

Methods: A modified Delphi process was conducted with members of selected American Association of Colleges of Pharmacy (AACP) affinity groups as the expert panel. Eighty-three potential topic areas across 12 domains were gathered via an informal literature review.

Gut microbiome and obesity in late adolescence: a case-control study in "Children of 1997" birth cohort.

Purpose: Although the gut microbiome is important in human health, its relation to adolescent obesity remains unclear. Here we assessed the associations of the gut microbiome with adolescent obesity in a case-control study.

Methods: In the "Children of 1997" birth cohort, participants with and without obesity at ~17.