Modulation of endothelin-1 release by a transmissible factor from ischemic myocardium.

The aim of this study was to detect the possible release from the ischemic rabbit myocardium of a factor capable of modulating the release of endothelin-1 (ET-1) from the peripheral vasculature. Isolated rabbit hearts were perfused on a Langendorff apparatus so that part of the coronary effluent was pumped directly into the arterial supply of isolated ears. Mean ET-1 outflow from ears perfused with fresh Krebs was 4.