Publications by authors named "J Chapelon"
Background: Body mass index (BMI) determines general corpulence and health, whatever age, sex or clinical background. Normal BMI (18.5-24.
View Article and Find Full Text PDFHigh-intensity Focused Ultrasound (HIFU) is a promising treatment modality for a wide range of pathologies including prostate cancer. However, the lack of a reliable ultrasound-based monitoring technique limits its clinical use. Ultrasound currently provides real-time HIFU planning, but its use for monitoring is usually limited to detecting the backscatter increase resulting from chaotic bubble appearance.
View Article and Find Full Text PDFDynamic Ultrasound Focusing and Centimeter-Scale Ex Vivo Tissue Ablations With a CMUT Probe Developed for Endocavitary HIFU Therapies.
Ivan M Suarez-Castellanos Geoffroy de Sallmard Guillaume Vanstaevel Alice Ganeau Christopher Bawiec Jean-Yves Chapelon
IEEE Trans Ultrason Ferroelectr Freq Control
November 2023
Article Synopsis
- Thermal ablation of localized prostate tumors using ultrasound-guided high-intensity focused ultrasound (USgHIFU) faces challenges, which may be improved by integrating advanced imaging and therapy techniques.
- Capacitive micromachined ultrasound transducers (CMUTs) offer advantages like miniaturization and higher efficiency compared to traditional piezoelectric transducers, leading to the development of a dual-mode USgHIFU probe for prostate cancer treatment.
- The feasibility of this CMUT-based probe was demonstrated through successful thermal ablation experiments on porcine liver tissue, showing it can effectively target localized tumors while enabling enhanced treatment techniques like dynamic focusing and probe movement.
Article Synopsis
- Focused ultrasound (FUS) shows potential for noninvasive neurostimulation, but the mechanisms behind its effectiveness remain unclear, prompting this study to explore its bioeffects on an invertebrate neural model.
- Researchers examined how different ultrasound parameters, like intensity and pulse duration, influenced the neurostimulation success rate (NSR) in the nervous system of Lumbricus terrestris, finding that higher values of these parameters significantly increased the NSR.
- The study revealed that the NSR could approach 100% with optimal settings, highlighting the importance of specific acoustic conditions for effective stimulation.
Article Synopsis
- The study investigates how focused ultrasound (FUS) stimulates neuronal signals in mouse brain slices, particularly in the hippocampus, to understand brain functions and potential treatments for neurological disorders.
- Using a mixed FUS/microelectrode array (MEA) platform, it characterizes the spatio-temporal dynamics of neural responses, showing that single FUS pulses can produce repeatable local field potentials (LFPs) with varying amplitudes, durations, and response delays.
- Findings suggest that FUS can effectively stimulate different neuronal networks in the hippocampus, advancing our understanding of ultrasound as a neurostimulation technique beyond repetitive pulse methods.