Impact of computer-aided detection prompts on the sensitivity and specificity of screening mammography.

Objectives: To determine the value of computer-aided detection (CAD) for breast cancer screening.

Design: Two sets of mammograms with known outcomes were used in two studies. Participants in both studies read the films with and without the benefit of a computer aid.

Assessing the impact of CAD on the sensitivity and specificity of film readers.

Aim: To assess the impact of computer-aided detection (CAD) prompts on film readers' sensitivity and specificity.

Material And Methods: Thirty-five readers read 120 films, including 44 cancers, 40 of which were prompted. All readers looked at all cases with and without prompts.

An evaluation of the impact of computer-based prompts on screen readers' interpretation of mammograms.

The NHS Breast Screening Programme is changing working practices in response to increased workload and manpower shortages. Radiographers are being trained as film readers. Computer aids are being considered.

Reproducibility of prompts in computer-aided detection (CAD) of breast cancer.

Aim: We evaluated the reproducibility of prompts using the R2 ImageChecker M2000 computer-aided detection (CAD) system.

Materials And Methods: Forty selected two-view mammograms of women with breast cancer were digitized and analysed using the ImageChecker on 10 separate occasions. The mammograms were chosen to provide both straightforward and subtle signs of malignancy.

Crystal structure of Escherichia coli UvrB C-terminal domain, and a model for UvrB-uvrC interaction.

A crystal structure of the C-terminal domain of Escherichia coli UvrB (UvrB') has been solved to 3.0 A resolution. The domain adopts a helix-loop-helix fold which is stabilised by the packing of hydrophobic side-chains between helices.