Publications by authors named "J Chabod"
Article Synopsis
- Pregnancy is a natural cause for anti-HLA immunization, but the frequency of this immunization is not well understood due to past studies using low sensitivity methods or being conducted too late after delivery.
- A new study using Luminex found that 54.4% of women at delivery showed anti-HLA immunization, with higher rates in women who had more children, reaching 74% in those with more than 2 deliveries.
- Factors such as soluble HLA-G levels influenced the presence of strong cytotoxic antibodies, and specific genetic variations were associated with a lower immunization rate in first-time pregnant women without miscarriages.
Anti-HLA antibody (Ab) monitoring is essential for the follow-up of transplant patients. However, it can be affected by drugs, especially Ab infused as a conditioning regimen for transplantation. ATG Fresenius, commonly used in this setting, is a polyclonal rabbit Ab raised against the Jurkat human T cell line (HLA-A3, 32; B7, 35).
View Article and Find Full Text PDFIntroduction: Spondylarthropathies (SpA) are characterized by abnormal immune responses including T cell activation. Cytotoxic T lymphocyte associated molecule-4 (CTLA-4) is involved in down-regulating immune responses. A soluble form of CTLA-4 (sCTLA-4), resulting from an alternative splicing, has been identified and was found increased in several autoimmune diseases.
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