Publications by authors named "J Cendelin"
Comparison of toric intraocular lens tilt and decentration measurement using dynamic Purkinje-meter and anterior segment optical coherence tomography.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
June 2024
Aims: To present a new method of dynamic Purkinje-metry and to verify it by comparison with a commercially available anterior segment optical coherence tomography CASIA2.
Patients And Methods: A dynamic Purkinje-meter with a movable fixation target was assembled. A coaxial circular pattern formed by infrared LEDs was projected onto the eye and evoked Purkinje images (1st, 3rd, 4th = P1, P3, P4).
Substitution of lost neurons by neurotransplantation would be a possible management of advanced degenerative cerebellar ataxias in which insufficient cerebellar reserve remains. In this study, we examined the volume and structure of solid embryonic cerebellar grafts in adult Lurcher mice, a model of olivocerebellar degeneration, and their healthy littermates. Grafts taken from enhanced green fluorescent protein (EGFP)-positive embryos were injected into the cerebellum of host mice.
View Article and Find Full Text PDFAdvances in cerebellar disorders: pre-clinical models, therapeutic targets, and challenges.
Expert Opin Ther Targets
November 2023
Article Synopsis
- Cerebellar ataxias (CAs) are complex neurological disorders with various causes and symptoms, and there are currently limited treatment options available.
- The discussion focuses on preclinical research models, the concept of cerebellar reserve, therapeutic strategies, and potential markers for monitoring treatment progress.
- Ongoing research is essential to develop effective therapies, considering the unique characteristics of each patient's condition, and to better understand how treatments for the cerebellum affect other brain areas.
Article Synopsis
- * This study examined edaravone’s potential effects on SCA1 using a mouse model over 13 weeks, assessing various functional and behavioral deficits.
- * The findings indicated that edaravone did not show any significant therapeutic benefits in improving behavioral dysfunctions or related disease symptoms in the SCA1 mice, challenging its potential as a treatment for this condition.
Purpose: The study evaluates the rate of postoperative formation of a pupillary membrane (PM) and posterior visual axis opacification (PVAO) in infants with and without primary IOL implantation during the first 4 months of infancy.
Methods: Medical records for 144 eyes (101 infants) operated between 2005 and 2014 were evaluated. A posterior capsulectomy and anterior vitrectomy were performed.