Natural Savannah Systems Within the "One Welfare" Approach: Part 1-Good Farmers' Perspectives, Environmental Challenges and Opportunities.

The Colombian Orinoquia is considered one of the eight most important ecosystems in the world. Savannah ecosystems play an essential role in providing ecosystem services. The objectives were (a) to explore and identify the perceptions of traditional farmers and institutional representatives regarding human well-being, animal welfare and the environment, and (b) to identify environmental challenges and opportunities for improvement based on the "One Welfare" concept.

A New Chapter for the : Elevating Our Impact and Vision.

Description Dr Juan A Sanchez, the new editor-in-chief of the , shares his vision for elevating the journal's influence by publishing high-quality, impactful research. Moving forward, the journal will introduce new initiatives, including more special issues and invited editorial commentaries, to foster a dynamic academic environment. Dr Sanchez invites the medical community to contribute and engage with the journal to advance medical knowledge and improve health care outcomes.

Genome-scale resources in the infant gut symbiont Bifidobacterium breve reveal genetic determinants of colonization and host-microbe interactions.

Bifidobacteria represent a dominant constituent of human gut microbiomes during infancy, influencing nutrition, immune development, and resistance to infection. Despite interest in bifidobacteria as a live biotic therapy, our understanding of colonization, host-microbe interactions, and the health-promoting effects of bifidobacteria is limited. To address these major knowledge gaps, we used a large-scale genetic approach to create a mutant fitness compendium in Bifidobacterium breve.

Trans-Mediated, Cis-Inhibited Paradoxal Activity of Enterotoxin (c-CPE) in Modulating Epithelial Permeability.

In the context of transdermal delivery, favoring the drug permeability of epithelia through convenient formulations would open new opportunities for local versus systemic drug delivery, envisaging higher patient comfort and an enhanced therapeutic effect. Ligands of tight junctions are interesting agents that enhance epithelial permeability by relaxing the protein complexes that form them. The C-terminal domain of enterotoxin (c-CPE), which binds claudins, one of the tight junction (TJ) components, has been explored here as a functional domain in modular recombinant proteins, to evaluate its ability to self-promote its paracellular epithelial passage in a Caco-2 cell monolayer model.

Inflow-to-Outflow Stent Frame Expansion, Ellipticity, and Decoupling in Evolut TAVR: Implications for Mid-term Hemodynamic Performance.

Background: The native aortic annulus for self-expanding transcatheter aortic valve replacement (TAVR) has variable ellipticity. A noncircular and underexpanded transcatheter aortic valve (TAV) may impact hemodynamic performance. This study aimed to quantify Evolut TAV (Medtronic) frame ellipticity and expansion 30 days post-TAVR and evaluate their impact on 1-year hypoattenuating leaflet thickening and 4-year hemodynamics.