Dually Fluorinated Unimolecular Micelles for Stable Oxygen-Carrying and Enhanced Photosensitive Efficiency to Boost Photodynamic Therapy against Hypoxic Tumors.

Tumor hypoxia is one of key challenges in deep tumor photodynamic therapy (PDT), and how to fix this issue is attracting ongoing concerns worldwide. This work demonstrates dually fluorinated unimolecular micelles with desirable and stable oxygen-carrying capacity, high cellular penetration, and integrative type I & II PDT for deep hypoxic tumors. Dually fluorinated star copolymers with fluorinated phthalocyanines as the core are prepared through photoinitiated electron/energy transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization under irradiation with NIR LED light at room temperature, followed by assembly into unimolecular micelles.

Genome-Wide Association Analysis of Boar Semen Traits Based on Computer-Assisted Semen Analysis and Flow Cytometry.

Semen quality and persistence are critical for evaluating the usability of individual boars in AI, a standard practice in pig breeding. We conducted GWASs on various semen traits of Duroc boars, including MOT, DEN, ABN, MMP, AIR, and ROS levels. These traits were assessed using FCM and CASA.

Exploring the potential anticancer targets and mechanistic pathways of essential oil based on network pharmacology.

This study aimed to assess the composition of essential oil (EBE) and identify potential targets for inhibiting human hepatocellular carcinoma cell proliferation. The plants were collected from four regions: Jiuzhi, Qinghai; Ruoergai, Sichuan; Aba, Sichuan; and Jiulong, Sichuan. Four EBEs (named No.

Building Bilayer MoS with Versatile Morphologies via Etching-And-Growth Coexisting Method.

The etch-engineering is a feasible avenue to tailor the layer number and morphology of 2D layered materials during the chemical vapor deposition (CVD) growth. However, less reports strengthen the etch-engineering used in the fabrication of high-quality transition metal dichalcogenide (TMD) materials with tunable layers and desirable morphologies to improve their prominent performance in electronic and optoelectronic devices. Here, an etching-and-growth coexistence method is reported to directly synthesize high-quality, high-symmetric MoS bilayers with versatile morphologies via CVD.

Improving sulforaphane content in broccoli sprouts by applying Se: transcriptome profiling and coexpression network analysis provide insights into the mechanistic response.

Sulforaphane (SF) is a sulfur (S)-containing isothiocyanate found in cruciferous vegetables and is known for its potent anticancer properties. Broccoli sprouts, in particular, are considered safe and healthy dietary choices due to their high SF content and other beneficial biological activities, such as enhanced metabolite ingestion. The application of selenium (Se) is an excellent approach to enhance the abundance of SF.