Registration of deaths in children under five years of age has improved in Mexico, however, the underreporting has not yet been eliminated.

Background: The underreporting of vital statistics poses a problem for the quality of information. To address underreporting, Mexico implemented the "Intentional Search for Children Deaths" in 2002.

Objective: To analyze trends in the underreporting of deaths in neonates and children under 5 years of age (U5) from 1992 to 2022 at the national level and by state.

From Semi-Infinite to Thin-Layer Diffusion─Effects of Finite Mass Transport on the Electrochemical Response of Redox Probes: Implications for Electroanalytical Measurements.

Electrochemistry in confined environments, that is, involving experimental configurations with spatial restrictions that affect the overall mass transport, is becoming a very attractive way of carrying out electroanalytical measurements for sensing, especially for the so-called thin-layer (TL) configuration, which ideally allows the complete conversion of the analytes under study in small volumes and short times. To improve the understanding of this kind of situation, general expressions for the current-potential-time and charge-potential-time responses of charge transfer processes taking place under finite diffusion conditions with two different configurations (no mass renovation, bounded diffusion; and effective mass renovation, unbounded diffusion) are discussed in this work. By using these expressions, it is possible to establish accurate limits for the attainment of TL conditions and to conclude that for bounded conditions, the charge is a more adequate quantity for electroanalytical purposes.

Using metabolic parameters to inform emergency care referral in a patient with a hyperglycemic induced acute kidney injury: a case report.

Objective: To describe the clinical reasoning and use of the American Diabetes Association (ADA) blood glucose and exercise guidelines in the face of an emerging acute glycemic crisis for a patient with type 2 diabetes mellitus receiving physical therapy for chronic ankle instability and fibromyalgia.

Case Description: Assessment of the patient's baseline blood glucose and ketone urinalysis revealed hyperglycemia and ketonuria, respectively. Shortly after testing, the patient became nauseous and vomited.

Empirical antibiotic therapy improves outcomes in mechanically ventilated patients with COVID-19: An emulated targeted trial within a prospective, multicentre cohort study.

Background: Bacterial pulmonary superinfections develop in a substantial proportion of mechanically ventilated COVID-19 patients and are associated with prolonged mechanical ventilation requirements and an increased mortality. Albeit recommended, evidence supporting the use of empirical antibiotics at intubation is weak and of low quality. The aim of this study was to elucidate the effect of empirical antibiotics, administered within 24hours of endotracheal intubation, on superinfections, duration of mechanical ventilation, and mortality in mechanically ventilated patients with COVID-19.

Multi-omics architecture of childhood obesity and metabolic dysfunction uncovers biological pathways and prenatal determinants.

Childhood obesity poses a significant public health challenge, yet the molecular intricacies underlying its pathobiology remain elusive. Leveraging extensive multi-omics profiling (methylome, miRNome, transcriptome, proteins and metabolites) and a rich phenotypic characterization across two parts of Europe within the population-based Human Early Life Exposome project, we unravel the molecular landscape of childhood obesity and associated metabolic dysfunction. Our integrative analysis uncovers three clusters of children defined by specific multi-omics profiles, one of which characterized not only by higher adiposity but also by a high degree of metabolic complications.