Publications by authors named "J Caspar Wohlfahrt"
As the primary innate immune cells of the brain, microglia play a key role in various homeostatic and disease-related processes. To carry out their numerous functions, microglia adopt a wide range of phenotypic states. The proteomic landscape represents a more accurate molecular representation of these phenotypes; however, microglia present unique challenges for proteomic analysis.
View Article and Find Full Text PDFBackground: The discovery of biomarkers in chronic subdural haematomas (CSDH) suggests that inflammation is part of CSDH pathophysiology. It is unknown whether inflammation reflects an independent CSDH driver or haematoma degeneration. This knowledge holds a potential target for anti-inflammatory treatment in patients at risk of CSDH.
View Article and Find Full Text PDFBackground: For aromatase inhibitor treatment (AIT) in breast cancer, there is an unresolved concern about ischaemic cardiotoxicity. We investigated the association between AIT and ischaemic cardiotoxicity in a prospective cohort of female patients with early breast cancer who received contemporary treatment in Denmark.
Methods: In this prospective cohort study in Denmark, we identified postmenopausal patients of any age diagnosed with breast cancer as recorded in the nationwide Danish Breast Cancer Cooperative Group (DBCG) clinical database between Jan 1, 2009, and Dec 31, 2020, and linked them to other nationwide registries.
Article Synopsis
- Objective
- : The study aimed to investigate the link between maternal diabetes during pregnancy and subtle changes in the heart structure and function of infants, specifically looking at the effects of both preexisting diabetes and gestational diabetes mellitus (GDM).
- Methods
- : Researchers analyzed data from 25,486 infants who underwent heart ultrasound within their first two months. They used linear regression to evaluate differences in heart measurements between infants exposed to maternal diabetes and those who were not.
- Results
- : Infants whose mothers had preexisting diabetes showed significant changes like thicker heart walls, smaller heart dimensions, lower blood flow, and faster heart rates compared to unexposed infants. Those born to mothers with GDM had similar,
Article Synopsis
- The study investigates the link between cardiac output (CO) and hypertension disorders during pregnancy, specifically preeclampsia, in women with and without fetal growth restriction (FGR).
- In a cohort of 906 pregnant women, findings suggest that low CO is a significant risk factor for preeclampsia, especially in those below 37 weeks of gestation, with women having FGR being at an even higher risk.
- The research highlights the potential importance of monitoring third-trimester cardiovascular function to identify women at risk for preeclampsia, although more studies are needed to confirm these findings.