Collective durotaxis of cohesive cell clusters on a stiffness gradient.

Many types of motile cells perform durotaxis, namely directed migration following gradients of substrate stiffness. Recent experiments have revealed that cell monolayers can migrate toward stiffer regions even when individual cells do not-a phenomenon known as collective durotaxis. Here, we address the spontaneous motion of finite cohesive cell monolayers on a stiffness gradient.

Motility and morphodynamics of confined cells.

We introduce a minimal hydrodynamic model of polarization, migration, and deformation of a biological cell confined between two parallel surfaces. In our model, the cell is driven out of equilibrium by an active cytsokeleton force that acts on the membrane. The cell cytoplasm, described as a viscous droplet in the Darcy flow regime, contains a diffusive solute that actively transduces the applied cytoskeleton force.

Unraveling the hidden complexity of quasideterministic ratchets: Random walks, graphs, and circle maps.

Brownian ratchets are shown to feature a nontrivial vanishing-noise limit where the dynamics is reduced to a stochastic alternation between two deterministic circle maps (quasideterministic ratchets). Motivated by cooperative dynamics of molecular motors, here we solve exactly the problem of two interacting quasideterministic ratchets. We show that the dynamics can be described as a random walk on a graph that is specific to each set of parameters.

Active wetting of epithelial tissues.

Development, regeneration and cancer involve drastic transitions in tissue morphology. In analogy with the behavior of inert fluids, some of these transitions have been interpreted as wetting transitions. The validity and scope of this analogy are unclear, however, because the active cellular forces that drive tissue wetting have been neither measured nor theoretically accounted for.

Author Correction: Formation of helical membrane tubes around microtubules by single-headed kinesin KIF1A.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.