Publications by authors named "J Carmona"
Article Synopsis
- The study evaluated the malignancy risk linked to ixekizumab in patients with rheumatological conditions through a systematic review of randomized controlled trials (RCTs) and long-term extension studies (LTEs).
- Meta-analyses indicated a low overall risk of malignancy, with Peto odds ratios showing varied results when compared to placebo and another drug, adalimumab.
- The research concluded that while ixekizumab generally poses a low risk for malignancy, certain conditions, like nonmelanoma skin cancer, may be exceptions for patients with psoriatic arthritis and axial spondyloarthritis.
Article Synopsis
- The study explores how health care professionals and surrogates (family members) of patients with severe neurological injuries perceive the use of Cognitive Motor Dissociation (CMD) in making decisions about goals of care (GoC) and research involvement.
- Findings show that 93% of participants would consider research participation if CMD indicated potential for recovery, compared to just 58% if CMD was negative.
- It highlights that health care professionals are more likely to alter GoC based on CMD results compared to surrogates, with religious beliefs influencing how strongly participants might change their goals of care.
There is a lack of information about transforming growth factor beta-1 (TGF-β) and cytokines contained in pure platelet-rich plasma (P-PRP) and release from pure-platelet-rich gel supernatants (P-PRGS) might be affected by the temperature and time factors; P-PRP from 6 heifers was activated with calcium gluconate. Thereafter, P-PRG and their supernatants (P-PRGS) were maintained at -80, -20, 4, 21, and 37 °C and collected at 3, 6, 12, 24, 48, 96, 144, 192, 240, and 280 h for subsequent determination of TGF-β, tumor necrosis factor alfa (TNF-α), interleukin (IL)-2, and IL-6; TGF-β concentrations were significantly ( < 0.05) higher in PRGS maintained at 21 and 37 °C when compared to PRGS maintained at 4, -20, and -80 °C; PRGS TNF-α concentrations were not influenced by temperature and time factors.
View Article and Find Full Text PDFIntroduction: The aim of this study was to investigate the genomic changes that occur in the development from dysplasia, cancer and to regional metastases in patients with oral cavity squamous cell carcinoma (OSCC).
Material And Methods: We included OSCC patients with lymph node metastases at diagnosis, treated with primary surgery at Rigshospitalet, University of Copenhagen in the period 2007-2014. The resected tumor specimens were evaluated by a pathologist, who marked areas of morphologically normal tissue and dysplasia surrounding the cancer, two areas from the cancer tissue, and one area within the lymph node metastases.
Introduction: Bovine subclinical mastitis (SCM) caused by Gram-positive bacteria is a major cause of economic loss in the dairy industry, exacerbated in situations where antimicrobial resistance is present. Pure platelet-rich plasma (P-PRP) may be a therapeutic alternative for SCM, when used alone or with antibiotics, such as sodium cloxacillin (SC). This study aimed 1) to evaluate the therapeutic efficacy of allogeneic P-PRP, SC, and their combination (P-PRP+SC) in cows with SCM caused by and by streptococci ( and ); 2) to determine the concentrations of somatic cells (SCC), interleukin 1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α) and TGF-β in milk samples of the cows.
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