Publications by authors named "J Carlos Manzano"
The epidemiological assessment of wine consumption usually has been obtained using self-reporting questionnaires. In this study, two metabolomic approaches, targeted and untargeted, were applied to 24-h urine samples from a cohort of La Rioja (Spain) (aged 52-78), comparing moderate and daily wine consumers (20 males and 13 females) without diet intervention, versus non-consumers (8 males and 35 females). Results showed that the non-targeted metabolomics approach has allowed for the annotation of sixteen compounds in 24-h urine samples from regular wine-consumers that were not detected in the urine of non-wine consumers.
View Article and Find Full Text PDFThis study estimates agricultural soil variables using a non-parametric machine learning technique based on Lipschitz interpolation. This method is adapted for the first time to learn spatio-temporal dynamics, accounting for two-dimensional spatial and one temporal coordinate inputs separately. The estimator is validated on real agricultural data, addressing challenges like measurement noise and quantization.
View Article and Find Full Text PDFObjective: Helicobacter pylori infections have been suggested to be associated with several extra gastric maladies, including hepatobiliary cancer (HBC). However, reports on the relationship between H. pylori infection and HBC showed variable and contrasting findings.
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- A study in Ecuador examined the effects of PFASs and pesticides on lung function in 381 adolescents, measuring their exposure to specific substances and assessing lung health over six years.
- Individual substances like PFOA, glyphosate, and ethylene thiourea showed slight associations with lung function improvements, but most other exposures did not have significant effects.
- Overall, the results suggest no strong evidence linking PFASs and pesticides with lung function changes in this population, especially after adjusting for various factors like household income and tobacco exposure.
Article Synopsis
- The study focuses on the need for faster treatment of immune checkpoint inhibitor-related pneumonitis (ICI-P), which is a serious condition in lung cancer patients.
- The implementation of a clinical care pathway algorithm aimed to shorten the time from diagnosis to treatment, showing a significant increase in the use of immunotoxicity order sets.
- While the direct time to treatment didn't significantly change, improvements in follow-up care and patient management were noted, emphasizing the importance of standardized practices in treating this condition.