Publications by authors named "J Carballido-Gamio"
Magnetic Resonance Assessment of Bone Quality in Metabolic Bone Diseases.
Semin Musculoskelet Radiol
October 2024
Metabolic bone diseases (MBDs) are a diverse group of diseases, affecting the mass or structure of bones and leading to reduced bone quality. Parameters representing different aspects of bone health can be obtained from various magnetic resonance imaging (MRI) methods such as proton MR spectroscopy, as well as chemical shift encoding-based water-fat imaging, that have been frequently applied to study bone marrow in particular. Furthermore, T2* mapping and high-resolution trabecular bone imaging have been implemented to study bone microstructure.
View Article and Find Full Text PDFBackground: Among older adults living with obesity, intentional weight loss (WL) improves prognosis of many comorbidities. However, concomitant decline in bone mineral density (BMD) limits overall benefit of WL by increasing osteoporotic fracture risk. Identification of intervention strategies to maximize body fat loss, while minimizing harm to the musculoskeletal system, is an important area of clinical research.
View Article and Find Full Text PDFA better understanding of how age-related bone loss affects the fracture-prone regions of the proximal femur could lead to more informed fracture-prevention strategies. Therefore, the aim of this work was to assess the spatio-temporal distribution of bone deterioration in older men and women with aging. A subset of 305 men (74.
View Article and Find Full Text PDFArticle Synopsis
- The review focuses on the latest research utilizing medical imaging techniques to assess bone fragility in individuals with diabetes, particularly type 2 diabetes (T2D) and to a lesser extent type 1 diabetes (T1D).
- Studies show a trend of reduced trabecular bone scores (TBS) in T2D patients, while findings in T1D are inconsistent, prompting researchers to adopt more advanced 3D imaging methods like high-resolution peripheral quantitative computed tomography (HR-pQCT).
- Despite the lack of comprehensive studies on bone fragility in T1D using QCT, recent literature indicates that T2D leads to notable impairments in bone geometry, suggesting a need for improved imaging approaches to better understand bone
Article Synopsis
- Osteoporosis is a widespread disease marked by low bone mass and deterioration that leads to an increased risk of fragility fractures, particularly in the vertebrae.
- Dual-energy X-ray absorptiometry (DXA) has been the standard method for diagnosing osteoporosis but comes with limitations, prompting interest in newer imaging techniques like CT and MRI.
- Advanced analysis methods such as texture analysis and finite element analysis can enhance fracture prediction when combined with CT and MRI, but standardized diagnostic criteria for these methods are still lacking, preventing easier adoption in clinical settings.