Publications by authors named "J Cann"
Interleukin (IL)-33 is released following tissue damage, causing airway inflammation and remodelling via reduced IL-33 (IL-33)/serum stimulation-2 (ST2) and oxidised IL-33 (IL-33)/receptor for advanced glycation end products (RAGE)/epidermal growth factor receptor (EGFR) pathways. This study aimed to identify associations of IL-33 with clinical outcomes and pathological mechanisms during viral lower respiratory tract disease (LRTD). Ultra-sensitive immunoassays were developed to measure IL-33, IL-33 and IL-33/sST2 complexes in samples from patients hospitalised with COVID-19.
View Article and Find Full Text PDFArticle Synopsis
- Benralizumab is a monoclonal antibody that targets the interleukin 5 receptor, causing quick reduction of eosinophils, which are associated with inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP).
- In a phase III trial, patients received either benralizumab or a placebo, with evaluations of eosinophil levels and inflammatory markers over time, showing significant decreases in eosinophils and other immune cells' concentrations.
- The findings indicate that benralizumab effectively and sustainably reduced eosinophils and related biomarkers in patients with CRSwNP, suggesting its potential as a treatment option for this condition.
Objective: Lupus nephritis (LN) is diagnosed by biopsy, but longitudinal monitoring assessment methods are needed. Here, in this preliminary and hypothesis-generating study, we evaluate the potential for using urine proteomics as a non-invasive method to monitor disease activity and damage. Urinary biomarkers were identified and used to develop two novel algorithms that were used to predict LN activity and chronicity.
View Article and Find Full Text PDFThe Erector Spinae Plane Block as Novel Therapy for Renal Colic: A Case Series.
J Ultrasound Med
January 2023
We present a 10-patient case series supporting the use of the erector spinae plane block (ESPB) as a novel approach for the treatment of acute pain from renal colic. An in-plane needle approach was used with either transverse or longitudinal orientation of the ultrasound probe on the affected side, in either seated or prone patient position. These cases showed significant improvement in patient reported pain; suggesting that the ESPB can be used safely and effectively for either primary or adjunctive treatment of acute pain due to renal colic in the emergency department.
View Article and Find Full Text PDFObjectives: To examine the numbers and patterns of patients presenting to an urban acute general hospital with acute mental health presentations and to further investigate any variation related to the COVID-19 pandemic.
Design: Retrospective observational cohort study.
Setting: An urban acute general hospital in London, UK, comprising of five sites and two emergency departments.